@русский кот, вообще не понял о чем Вы, но вот: "Three phenomena characterize addiction: craving (preoccupation/anticipation), binge/intoxication, and withdrawal/negative affect. Impulsivity and positive reinforcement often dominate the first stages, driving the motivation for drug seeking, and compulsivity and negative reinforcement dominate the terminal stages of the addiction cycle. Addictive drugs induce adaptive changes in gene expression in brain reward regions, including the striatum, representing a mechanism for tolerance and habit formation with craving and negative affect that persist long after consumption ceases. These neuroadaptive changes are key elements in relapse. Once an individual becomes addicted, the clinical options are untargeted and only partially effective. To what extent are the processes involved in the initiation and maintenance of drug use influenced by inherited variation, such that new therapies and preventive strategies could be developed and better targeted to individuals?" — Genes and Addictions (2009); я это не читал, просто попалось. Экспрессия генов это и есть по сути эпигенетика, которое в свою очередь тоже записывается в генах, в так называемому "мусорному ДНК/РНК".